A Mouse Model for the Human Pathogen Salmonella Typhi
نویسندگان
چکیده
منابع مشابه
A mouse model for the human pathogen Salmonella typhi.
Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoietic stem and progenitor cells are able to support S. Typhi replication and pers...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2010
ISSN: 1931-3128
DOI: 10.1016/j.chom.2010.09.003